Estimulación cerebral profunda en enfermedad de Parkinson / Deep brain stimulation in Parkinson's disease
Rev. méd. Chile
;
146(5): 562-569, mayo 2018. tab, graf
Article
in Spanish
| LILACS
| ID: biblio-961432
ABSTRACT
Background:
Deep brain stimulation is an essential therapeutic tool in Parkinson's disease.Aim:
To assess the results of a series of patients with Parkinson's disease treated with micro-electrode guided subthalamic nucleus stimulation. Material andMethods:
Twenty patients with idiopathic Parkinson's disease were studied (10 males). Three months after surgery, we analyzed the change in motor disturbances, medication need to control symptoms and quality of life.Results:
We observed a significant improvement in all the assessed variables. Motor involvement determined as OFF hours and expressed as percentage of the day changed from 30 ± 15 to 10 ± 7% in the preoperative and postoperative periods, respectively. ON hours without dyskinesia changed from 17 ± 16 to 78 ± 21%. ON hours with dyskinesia changed from 53 ± 23 to 12 ± 15%. Medication need changed from 1,505 ± 499 to 1,214 ± 528 levodopa equivalents. Parkinson's Disease Questionnaire 39 score changed from 62.9 ± 22.7 to 34.3 ± 18.5. During the 5-year follow-up a continuous improvement of symptoms was observed.Conclusions:
Micro-electrode guided subthalamic nucleus functional surgery in patients with Parkinson's disease has good immediate and late results.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Parkinson Disease
/
Subthalamic Nucleus
/
Deep Brain Stimulation
Type of study:
Observational study
/
Qualitative research
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2018
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad del Desarrollo/CL
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