Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica
Rev. bras. farmacogn
;
28(5): 564-567, Sept.-Oct. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-977721
ABSTRACT
Abstract The chemical investigation of the n-hexane fraction of Salvadora persica L., Salvadoraceae, seeds afforded a new stearic acid ester, salvastearolide, together with five other phytosteroids identified as stigmasterol, β-sitosterol, Δ7-campesterol, Δ7-avenasterol and campesterol. Their structures were established on the basis of extensive spectroscopic methods including 1D and 2D NMR experiments and HRESI mass spectrometry. In addition, salvastearolide and the isolated fractions were tested for their cytotoxicity against human cancer cell lines MCF-7, MDA-MB-231 and HT-29. The n-hexane fraction exhibited significant anti-proliferative effect against human breast cancer cell line MCF-7 (IC50 50 µg/ml), while salvastearolide possessed a weak cytotoxic effect against MCF-7 cells with IC50 103.98 µg/ml.
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2018
Type:
Article
Affiliation country:
Saudi Arabia
/
South Korea
Institution/Affiliation country:
Jazan University/SA
/
King Abdulaziz University/SA
/
Kookmin University/KR
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