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Ramipril can alleviate the accumulation of renal mesangial matrix in rats with diabetic nephropathy by inhibiting insulin-like growth factor-1
Ren, Wei; Zhao, Chen; Wang, Yan; Fang, Yuan; Huang, Zhenzhen; Chen, Wei; Wang, Lihua; Hu, Wen; Wang, Ke; Ni, Lijun.
  • Ren, Wei; Anhui Medical University. Anhui Provincial Hospital Affiliated. Department of Nephrology. Hefei. CN
  • Zhao, Chen; Anhui Medical University. Anhui Provincial Hospital Affiliated. Department of Nephrology. Hefei. CN
  • Wang, Yan; Anhui Medical University. Anhui Provincial Hospital Affiliated. Department of Nephrology. Hefei. CN
  • Fang, Yuan; Anhui Medical University. Anhui Provincial Hospital Affiliated. Department of Nephrology. Hefei. CN
  • Huang, Zhenzhen; Anhui Medical University. Anhui Provincial Hospital Affiliated. Department of Nephrology. Hefei. CN
  • Chen, Wei; Anhui Medical University. Anhui Provincial Hospital Affiliated. Department of Nephrology. Hefei. CN
  • Wang, Lihua; Anhui Medical University. Anhui Provincial Hospital Affiliated. Department of Nephrology. Hefei. CN
  • Hu, Wen; Anhui Medical University. Anhui Provincial Hospital Affiliated. Department of Pathology. Hefei. CN
  • Wang, Ke; Anhui Medical University. Anhui Provincial Hospital Affiliated. Department of Nephrology. Hefei. CN
  • Ni, Lijun; Anhui Medical University. Anhui Provincial Hospital Affiliated. Department of Nephrology. Hefei. CN
Acta cir. bras ; 34(1): e20190010000007, 2019. tab, graf
Article in English | LILACS | ID: biblio-983684
ABSTRACT
Abstract

Purpose:

To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN).

Methods:

The Sprague Dawley rats were divided into normal control (NC) group (n = 12), DN group (n = 11), and DN+RAM group (n = 12). The ratio of renal weight to body weight (RBT), fasting blood glucose (FBG), HbA1c, 24-h urine protein (TPU), blood urea nitrogen (BUN), creatinine (Cr), renal pathological changes, the levels of IGF-1, fibronectin (FN), type IV collagen (Col-IV), and matrix metalloproteinases (MMP)-2 were compared among the groups.

Results:

Compared with NC group, the RBT, FBG, HbA1c, TPU, BUN, Cr, and RMM in DN group were significantly increased (P < 0.05), the IGF-1, FN, and Col-IV were significantly upregulated (P < 0.05), while MMP was significantly downregulated (P < 0.05). Compared with DN group, the indexes except for the FBG and HbA1c in DN+RAM group were significantly improved (P < 0.05), among which IGF-1 exhibited significant positive correlation with TPU(r=0.937), FN(r=0.896) and Col-IV(r=0.871), while significant negative correlation with MMP-2 (r=-0.826) (P<0.05).

Conclusion:

RAM may protect the kidneys by suppressing IGF-1 and mitigating the accumulation of RMM.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Insulin-Like Growth Factor I / Angiotensin-Converting Enzyme Inhibitors / Ramipril / Diabetic Nephropathies / Mesangial Cells Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Anhui Medical University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Insulin-Like Growth Factor I / Angiotensin-Converting Enzyme Inhibitors / Ramipril / Diabetic Nephropathies / Mesangial Cells Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Anhui Medical University/CN