Comparison of serum levels of tri-iodothyronine [T3], thyroxine [T4], and thyroid-stimulating hormone [TSH] in preeclampsia and normal pregnancy

ABSTRACT

The physiological changes in thyroid gland during pregnancy have been suggested as one of the pathophysiologic causes of preeclampsia. The aim of this study was comparison of serum levels of Tri-iodothyronine [T3], Thyroxine [T4], and Thyroid-Stimulating Hormone [TSH] in preeclampsia and normal pregnancy. In this case-control study, 40 normal pregnant women and 40 cases of preeclamsia in third trimester of pregnancy were evaluated. They were compared for serum levels of Free T3 [FT3], Free T4 [FT4] and TSH. The data was analyzed by SPSS software with the use of t-student, Chi-square, Independent sample T-test and Bivariate correlation test. P parity between two groups [=0.206]. Normal pregnant women were not significantly different from preeclamsia cases in the view of FT3 level [1.38 pg/ml vs. 1.41 pg/ml, =0.8.03], FT4 level [0.95 pg/ml vs. 0.96 pg/ml, =0.834] and TSH level [3.51 micro IU/ml, =0.386]. The findings of the present study do not support the hyothesis that changes in FT3, FT4 and TSH levels could be possible etiology of preeclamsia