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[Occult HBV infection in Rafsanjanese blood donors]
Modares Journal of Medical Sciences, Pathobiology. 2008; 11 (3-4): 81-86
in Fa | IMEMR | ID: emr-118980
Responsible library: EMRO
ABSTRACT
Occult hepatitis B infection is a form of hepatitis in which despite of absence of detectable HBsAg, HBV-DNA is present in peripheral blood of patients. This clinical form of B hepatitis creates some problems for the Iranian blood transfusion services. Therefore, the aim of this study was the evaluation of status of occult hepatitis B infection in the Rafsanjanese blood donors. In this cross-sectional study, total of 3700 blood donor samples were collected and tested for HBsAg and anti-HBs using ELISA. The HBsAg negative and anti-HBc positive samples were selected and screened for HBV-DNA using PCR. Results of current study indicated that 352 [9.5%] of 3700 blood samples were HBsAg- and anti-HBc+. HBV-DNA was detected in 57 [16.1% of HBsAg- and anti-HBc+ and 1.54% of total samples] samples. Results of this study are in agreement with our previous studies in the prevalence of OBI. Therefore, it seems that occult hepatitis B infection rate is high in the Iranian blood donors and probably is one of the main causes of post-transfusion hepatitis
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Index: IMEMR Main subject: Blood Donors / Enzyme-Linked Immunosorbent Assay / Polymerase Chain Reaction / Cross-Sectional Studies / Hepatitis B Antibodies / Hepatitis B Surface Antigens Type of study: Prevalence_studies Limits: Humans Language: Fa Journal: Modares J. Med. Sci., Pathobiol. Year: 2008
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Index: IMEMR Main subject: Blood Donors / Enzyme-Linked Immunosorbent Assay / Polymerase Chain Reaction / Cross-Sectional Studies / Hepatitis B Antibodies / Hepatitis B Surface Antigens Type of study: Prevalence_studies Limits: Humans Language: Fa Journal: Modares J. Med. Sci., Pathobiol. Year: 2008