Natriuretic effect of glucagon in starved and fed rats

The study was carried out on 40 male albino rats [a fed group and a starved group]. Half of the animals in each group received intravenous injection [1.5 ng/g b. wt.] for 4 consecutive days. Glucagon treatment prevented starvation induced sodium retention and was observed to enhance the glomerular filtration rate [GER] and to lack an influence on the renal Na+ - K+ ATPase enzyme. So, it can be concluded that the natriuretic action of glucagon can be considered to be performed at the glomerular level