Protective effects of Sonchus asper [L.] against KBrO[3]-induced oxidative stress in rat testis
Pakistan Journal of Pharmaceutical Sciences. 2013; 26 (3): 567-570
in En
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| ID: emr-142618
Responsible library:
EMRO
ABSTRACT
Sonchus asper is used traditionally in the treatment of kidney inflammation, hormonal imbalance and impotency. Sonchus asper methanolic extract [SAME] was investigated for its possible preventive effect against potassium bromate [KBrO[3]] induced oxidative damages in male rats using biochemical, molecular and histopathological markers in this study. 5 groups, each group of 6 rats were taken kept under standard conditions. Group 1 remained untreated while Group II was given 20 mg/kg KBrO[3] orally [in aqueous saline] and Group III, and IV were treated with 100; 200 mg/kg b.w., of SAME after 48 h of KBrO[3] treatment. KBrO[3] administration in rats significantly altered [P<0.01] the serum level of reproductive hormones, activities of antioxidant enzymes and glutathione contents [GSH], which was significantly reversed P<0.001] by co-treatment of 100 mg/kg and 200 mg/kg b.w., SAME. Administration of SAME in rats also significantly P<0.001] reversed the lipid peroxidation induced by KBrO[3] in rats, which could be due to the presence of some plant bioactive constituents
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Index:
IMEMR
Main subject:
Plants, Medicinal
/
Rats
/
Testis
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Bromates
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Plant Extracts
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Lipid Peroxidation
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Oxidative Stress
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Glutathione
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Hormones
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Antioxidants
Limits:
Animals
Language:
En
Journal:
Pak. J. Pharm. Sci.
Year:
2013