Expression of T-cell immunoglobulin- and mucin-domain-containing molecule-3 on lymphocytes from Henoch-Schoenlein purpura patients
Iranian Journal of Pediatrics. 2013; 23 (3): 345-348
in English
| IMEMR
| ID: emr-143203
ABSTRACT
To investigate T-cell immunoglobulin domain and mucin domain-containing molecule-3 [Tim-3] and its ligand galectin-9 mRNA expression in peripheral blood mononuclear cells [PBMCs] from Henoch-Schoenlein Purpura [HSP] patients. Quantitative real-time reverse transcription-polymerase chain reaction [PCR] was used to examine the mRNA expression of Tim-3 and its ligand galectin-9 in PBMCs from HSP patients. ELISA methods were used to examine the levels of serum IFN-gamma and immunoglobulin A1 [IgA1]. The Spearman rank test was used for correlation analysis between Tim-3, galectin-9 mRNA expression and serum IFN-gamma and IgA1 levels, respectively. The results showed that Tim-3 and galectin-9 mRNA expression was obviously higher in patients, which was closely correlated with serum IFN-gamma and IgA1, respectively. The results suggested that Tim-3/Tim-3L may be related to the pathogenesis of HSP
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Immunoglobulin A
/
Immunoglobulins
/
Enzyme-Linked Immunosorbent Assay
/
Lymphocytes
/
T-Lymphocytes
/
Interferon-gamma
/
Real-Time Polymerase Chain Reaction
/
Membrane Proteins
Limits:
Humans
Language:
English
Journal:
Iran. J. Pediatr.
Year:
2013
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