Fluoride formation and excretion following halothane, enflurane and methoxyflurane anesthesia

Serum and urine fluoride and serum uric acid were determined in sixty patients receiving halothane, enflurane and methoxyflurane [20 in each group]. On the day of operation, there was significant increase in serum uric acid and fluoride concentration with methoxyflurane, while in halothane and enflurane groups fluoride in serum and urine were significantly elevated. Serum uric acid decreased to preoperative level, in the three anaesthetics at the third and seventh postoperative days. The increased level of fluoride with the three anaesthetics still persisted in methoxyflurane group, while it was disappeared at the seventh postoperative day in the other two groups. Regression analysis revealed no correlation between serum uric concentration and level of fluoride in the blood with methoxyflurane