Target antigens for perinuclear antineutrophil cytoplasmic antibodies in Iranian patients with ulcerative colitis
Middle East Journal of Digestive Diseases. 2014; 6 (4): 203-207
in English
| IMEMR
| ID: emr-148753
ABSTRACT
Patients with ulcerative colitis [UC] carry autoantibodies such as perinuclear antineutrophil cytoplasmic antibodies [p-ANCA]. The aim of the present study was to evaluate the target antigens for p-ANCA in Iranian patients with UC. p-ANCA target antigens including elastase, lactoferrin, cathepsin G, myeloproxidase, lysozyme, and bactericidal permeability increasing protein [BPI] were determined in 113 patients with UC using enzyme-linked immunosorbent assay [ELISA]. 59.2% of the patients were positive for at least one antigen and p-ANCA directed against lactoferrin, elastase, lysozyme, cathepsin G, Bactericidal permeability increasing protein, and myeloproxidase in 31.5%, 25.9%, 8.3%, 7.4%, 5.6%, and 0% of the patients, respectively. The highest prevalence of p-ANCA was observed against lactoferrin and elastase. Also, myeloproxidase was not an antigen for p-ANCA among our patients
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pancreatic Elastase
/
Muramidase
/
Peroxidase
/
Antibodies, Antineutrophil Cytoplasmic
/
Cathepsin G
/
Lactoferrin
/
Antigens
Type of study:
Case report
Limits:
Animals
Language:
English
Journal:
Middle East J. Dig. Dis.
Year:
2014
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