Interferon-gamma release assay for detection of latent tuberculosis infection in casual and close contacts of tuberculosis cases
EMHJ-Eastern Mediterranean Health Journal. 2011; 17 (10): 749-753
in English
| IMEMR
| ID: emr-158728
ABSTRACT
The tuberculin skin test [TST] has many limitations for the diagnosis of latent tuberculosis [TB] infection. The aim of this study in Egypt was to estimate the usefulness of an interferon-gamma release assay [IFN-gamma] assay for the detection of latent TB infection in contacts of active TB cases. A total of 116 participants were enrolled and divided into 3 groups community controls, casual [laboratory and clinic] contacts and close [household] contacts. Subjects diagnosed with latent TB infection by TST were 11.5% of controls, 71.1% of casual contacts and 29.6% of close contacts. Subjects diagnosed as latent TB infection by IFN-gamma assay [QuantiFERON-TB Gold In-Tube] were 5.9% of controls, 31.0% of casual contacts and 33.3% of close contacts. The overall agreement between TST and IFN-gamma was 66.7% [K= 0.28]. The IFN-gamma method could be more helpful than TST for detection of latent TB infection in contacts
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Tuberculin Test
/
Cross-Sectional Studies
/
Interferon-gamma
/
Latent Tuberculosis
Type of study:
Prevalence study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
East Mediterr Health J.
Year:
2011
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