Relationship between seminal melatonin with sperm parameters, DNA Fragmentation and nuclear maturity in Intra-Cytoplasmic sperm injection candidates

ABSTRACT

Objective: Melatonin, the chief secretory product of the pineal gland, regulates dynamic physiological adaptations that occur in seasonally breeding mammals as a response to changes in daylight hours. Because of the presence of melatonin in semen and the membrane melatonin receptor in spermatozoa, the impact of melatonin on the regulation of male infertility is still questionable. The aim of this study was to determine the effects of endogenous melatonin on human semen parameters [sperm concentration, motility and normal morphology], DNA fragmentation [DF] and nuclear maturity