miR-302b-3p promotes self-renewal properties in leukemia inhibitory factor-withdrawn embryonic stem cells

ABSTRACT

Objective: Embryonic stem cells [ESCs] are regulated by a gene regulatory circuitry composed of transcription factors, signaling pathways, metabolic mediators, and non-coding RNAs [ncRNAs]. MicroRNAs [miRNAs] are short ncRNAs which play crucial roles in ESCs. Here, we explored the impact of miR-302b-3p on ESC self-renewal in the absence of leukemia inhibitory factor [LIF]