Effect of sulfonylurea on platelet aggregation in diabetes mellitus

ABSTRACT

The platelets of many patients with diabetes mellitus are abnormally sensitive to the effect of aggregatory agents in vitro. It has been proposed that this abnormal platelet function may play a role in pathogenesis of vascular disease in diabetic subjects, The present study reports the platelet aggregation pattern of different diabetic groups. Patients controlled on diet, by insulin and biguanide group of drugs showed increased platelet aggregation to ADP and collagen, while the patients controlled by sulfonylurea showed a normal aggregation. The alterations in platelet function did not correlate with blood glucose level, suggesting, therefore, that it is the effect of drug itself