Interaction of amantadine and phencyclidine with the nicotinic acetylcholine receptor/channel from torpedo electric organ and philosamia ricini brain
Alexandria Journal of Pharmaceutical Sciences. 1994; 8 (3): 181-185
in En
| IMEMR
| ID: emr-31636
Responsible library:
EMRO
ABSTRACT
In vitro interaction of amantadine and phencyclidine [PCP] with the nicotinic acetylcholine receptor/channel from Philosamia ricini brain and Torpedo electric organ was studied using [3H]PCP as channel probe. The results showed that binding of [3H]PCP to ionic channel of P. ricini brain was potentiated by amantadine, but the binding to ionic channel of Torpedo membranes was inhibited [Ki value is 2 mM]. Amantadine was suggested to act as agonist for ionic channel in insect brain. In addition, Scatchard analysis of the binding indicated at least two sites in P. ricini brain [a high affinity site with kd 5.3 mM and a low affinity site with kd 21.7 nm]. PCP inhibited the binding of [3H]PCP to ionic channel of P. ricini brain and Torpedo membranes with Ki values [0.013-0.016 mM] and 0.8 mM, respectively
Search on Google
Index:
IMEMR
Main subject:
Pharmacology
/
Phencyclidine
/
Receptors, Nicotinic
Language:
En
Journal:
Alex. J. Pharm. Sci.
Year:
1994