Reactions with spiroepoxy-alkanones. part III+ reaction of spirooctanones with dimethylamine aldehyde and then thiourea

Spirooctanones I react with dimethylamine at different conditions to give compounds II and III, and in the presence of aldehydes give IV. Compounds IV react with thiourea to give V, which undergoes cyclization with chloroacetic acid to give VI. Compounds VI condensed with dimethylamino-benzaldehyde to give VII. Some of the prepared compounds are biologically active