Novel coumarins of potential adrenergic antagonistic activity

ABSTRACT

A series of 1-[8-methyl-4-phenyl-coumarin-7-yloxy]-3-[substituted amino] propan-2-ol [10-18], 1-[substituted coumarinyloxy]-3-[substituted-amino] propane [19-35], and 6 or 7 [[3.t.butyl-5-oxazolidinyl] methoxy substituted coumarins [36-39] were prepared to study the effect of change of structure on the beta- adrenergic antagonistic activity. The preliminary pharmacological tests were carried out, the results were given and a conclusion was drawn