Synthesis and Hiv-1 activity of some novel 2,2 - diphenylamine derivatives

ABSTRACT

A number of new 2,2'-diphenylamine derivatives have been synthesized through reacting the dihydrazide 3 with acid anhydrides, carbonyl compounds, isothiocyanates, and CS2/KOH/hydrazine hydrate to give 4, 5, 7, and 10, respectively. Furthermore, cyclization of 5 and 7 have been achieved. 4b, 5g, 7a, and 9 have been shown to possess moderate anti-HIV activities. Compound 5a was pleaded active in the in vitro anticancer screening program. The intermediate 3 had been shown to fulfill the requirements of good synthones to design and synthesize new molecules