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[Urticarian vasculitis. a case report after sulfamethoxazole-trimethoprime ingestion]
Tunisie Medicale [La]. 2005; 83 (11): 714-716
in French | IMEMR | ID: emr-75288
ABSTRACT
Urticarian vasculitis [UV] is an anatomoclinical disorder characterized by the association of urticarian papules lasting for more than 24 hours with histological cutaneous vasculitis. Several etiologies are associated with the disease. We report the case of a 30-year-old woman with a-two-month history of urticarial purpuric and necrotic cutaneous lesions of the low limbs. These lesions occurred after oral sulfam‚thoxazole-trim‚thoprime ingestion, 2 weeks before the skin eruption. Histological examination revealed a leucocytoclasic vasculitis and direct immunofluorescence showed a perivascular IgG and C3 deposits. Immunological, allergological and radiological investigations were normal. The pharmacological enquiry confirmed the imputability of sulfam‚thoxazole-trim‚thoprime in the onset of skin eruption; Mild cutaneous improvement was observed after 3 months of treatment with prednisone 0,5 mg/Kg/day. Drug induced urticaria constitutes a rare etiology of UV. Sulfam‚thoxazole-trimethoprime imputability has not been reported before among the drug responsible for UV. Management of patients is difficult and improvement usually occurs after several months because of the resistance of the skin lesions
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Index: IMEMR (Eastern Mediterranean) Main subject: Urticaria / Trimethoprim, Sulfamethoxazole Drug Combination / Vasculitis, Leukocytoclastic, Cutaneous Type of study: Case report Limits: Female / Humans Language: French Journal: Tunisie Med. Year: 2005

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Index: IMEMR (Eastern Mediterranean) Main subject: Urticaria / Trimethoprim, Sulfamethoxazole Drug Combination / Vasculitis, Leukocytoclastic, Cutaneous Type of study: Case report Limits: Female / Humans Language: French Journal: Tunisie Med. Year: 2005