Role of IL-6, sIL-6R, IL-1 beta, TNF-alpha, and B2M in pathophysiology and prognosis of multiple myeloma
Assiut Medical Journal. 2007; 31 (1): 145-156
in En
| IMEMR
| ID: emr-81910
Responsible library:
EMRO
ABSTRACT
Cytokines control myeloma cell proliferation, differentiation, apoptosis and tumor-induced bone marrow destruction. The present study was designed to estimate the serum levels of interleukin-6 [IL-6], soluble IL-6 receptor [sIL-6R], IL-1 beta, tumor necrosis factor-alpha [TNF-alpha], and beta-2 microglobulin [beta 2M] in multiple myeloma [MM] in an attempt to elucidate their role in the disease, to study their levels in different immunologic types of MM, and to evaluate the effect of therapy on these levels. The study included 40 patients with MM, 20 newly diagnosed [group I] and 20 patients receiving treatment [group II]. Ten patients received therapy for
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Index:
IMEMR
Main subject:
Prognosis
/
Blood Protein Electrophoresis
/
Cytokines
/
Beta 2-Microglobulin
/
Interleukin-6
/
Interleukin-1
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Receptors, Interleukin-6
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Tumor Necrosis Factors
Limits:
Female
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Humans
/
Male
Language:
En
Journal:
Assiut Med. J.
Year:
2007