Oxidative stress and interleukin-1 beta in serum and skin lesions of patients with generalized vitligo
Assiut Medical Journal. 2007; 31 (3): 161-168
in En
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| ID: emr-81929
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ABSTRACT
The etiology of vitiligo is unknown. Increased oxidant stress may explain melanocyte dysfunction and destruction. Increases in pro-oxidants as well as decreases in anti-oxidant agents have been reported in patients with vitiligo. In this study we investigated the role of oxidative stress by determining the levels of the free radical nitric oxide [NO] and the antioxidant systems superoxide dismutase [SOD], and L-ascorbic acid in addition to interleukin-1beta [IL-1beta] in both serum and tissue of lesional skin in patients with generalized vitiligo. Levels of NO and IL-1beta were significantly higher in the serum and tissue of lesional skin of patient with generalized vitiligo compared to the control group. While L-ascorbic acid and superoxide dismutase levels were significantly reduced in patients compared to controls. Extent of vitiligo showed a significant positive correlation with tissue levels of IL-1beta. Oxidative stress may play a role in the pathogenesis of generalized vitiligo with increased production of NO and decreased SOD activity and ascorbic acid levels. IL-1beta could have a role in the pathogenesis of vitiligo possibly through the induction of NO production
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Index:
IMEMR
Main subject:
Ascorbic Acid
/
Skin
/
Superoxide Dismutase
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Interleukin-1
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Oxidative Stress
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Nitric Oxide
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Antioxidants
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Assiut Med. J.
Year:
2007