[Evaluation of serum levels of IL-L alpha, TGF-Beta, TNF-alpha, IFN-alpha, IFN-Omega, IL-1 alpha, TGH-beta, cortisol and immunoglobulins in Islamic ramadan fasting]
IJEM-Iranian Journal of Endocrinology and Metabolism. 2007; 9 (2): 201-204
in Fa
| IMEMR
| ID: emr-82708
Responsible library:
EMRO
ABSTRACT
This research aimed determining the levels of cortisol, immunoglobulins and major serum cytokines, following Ramadan fasting, as immune response indexes. For this before and after Ramadan fasting study, twenty-five students residing at the dormitory of the Tehran University of Medical Sciences were selected. All cytokines levels [IL-1alpha TGF-beta, TNF-alpha, IFN-alpha, IFN-omega] were determined by the ELISA method, Immoglobulines were determined by the Radial Immunodiffusion [SRID] technique and cortisol levels were measured by EIA too. While IFN-omega a showed a considerable increase after Ramadan fasting [P<0.01], IFN-alpha and TNF-alpha had decreased [P >/= 0.5 and <0.02 respectively]. Serum level of TGF-beta increased but not significantly [P>0.3]; cortisol also increased after one month of fasting [P<0.05]. Serum IL-1alpha had a non-significant decrease [P >/= 0.5]. Although IgG and IgM levels showed no significant increase, IgA levels showed significant decrease [P<0.5]. Our data revealed that Ramadan fasting increased IFN-omega, while decreasing TNF-alpha and IgA levels; ramadan fasting can probably increase T-Cell function, lower the inflammatory appreance rate and affect immunoglubulin production
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Index:
IMEMR
Main subject:
Enzyme-Linked Immunosorbent Assay
/
Hydrocortisone
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Interferon Type I
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Transforming Growth Factor beta
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Fasting
/
Interleukin-1
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Tumor Necrosis Factor-alpha
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Islam
Limits:
Humans
Language:
Fa
Journal:
Iran. J. Endocrinol. Metab.
Year:
2007