Biodistribution of [64 Cu] pyruvaldehyde-bis [N4-methylthiosemicarbazone] complex in fibrosarcoma-bearing rats
Iranian Journal of Nuclear Medicine. 2007; 15 (27): 9-15
in En, Fa
| IMEMR
| ID: emr-94256
Responsible library:
EMRO
ABSTRACT
[64]Cu-pyruvaldehyde-bis [N[4]-methylthiosemicarbazone] [64]Cu-PTSM] is one of the most important copper radiopharmaceuticals used in clinical experiments. In this work, copper-64 [T[1/2]=12.33 h] production has been presented followed by the synthesis of the complexing agent, PTSM, and its structure was confirmed by common spectroscopic methods followed by radiolabeling with [64] Cu-actetate. The tracer was finally administered to fibrosarcoma-bearing rats and the biodistribution was determined in critical tissues as well as tumor. The final radiopharmaceutical solution underwent common quality control tests for animal injection a radiochemical purity >95% was determined. A significant tracer tumor uptake was observed 2 hours post injection. Tumonmuscle and tumonblood ratios were shown to be 8 and 6 respectively. [64]Cu-PTSM prepared in this report is a good candidate for tumor therapy as well as diagnosis for national use
Search on Google
Index:
IMEMR
Main subject:
Organometallic Compounds
/
Rats
/
Thiosemicarbazones
/
Copper Radioisotopes
/
Radiopharmaceuticals
Limits:
Animals
Language:
En
/
Fa
Journal:
Iran. J. Nucl. Med.
Year:
2007