Inhibition of bovine brain acetylcholinesterase by aluminum
Braz. j. med. biol. res
;
27(11): 2635-8, Nov. 1994. graf
Article
in English
| LILACS
| ID: lil-153985
ABSTRACT
We report the in vitro inhibitory effect of very low concentrations of aluminum salts (IC50 = 4.1 x 10-12M) on bovine brain acetylcholinesterase (AChE). The enzymatic assays were performed using acetylcholine bromide in a buffered pH 7.4 solution at 37§C. The relevant enzyme interacting species is the Al3+ ion, whose concentrations were fixed at pM levels by a citrate metal ion buffer system. The IC50 demonstrates that Al3+ is a potent inhibitor of AChE
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Index:
LILACS (Americas)
Main subject:
Acetylcholinesterase
/
In Vitro Techniques
/
Cerebrum
/
Aluminum
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1994
Type:
Article
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