Reversão de hipertrofia ventricular esquerda após o uso de benazepril / Reversal of Left Ventricular Hypertrophy After Benazepril
Arq. bras. cardiol
; 62(4): 251-254, abr. 1994. graf
Article
in Pt
| LILACS
| ID: lil-156270
Responsible library:
BR1.1
ABSTRACT
PURPOSE--To assess the effects of benazepril (ACE inhibitor) on arterial blood pressure (ABP) and left ventricular mass index (LVMI). METHODS--Nineteen patients (7 men, 12 women) with mean age 38.2 +/- 10.2 years, with mild to moderate hypertension were evaluated. Besides raised blood pressure, the necessary inclusion criterion was the presence of left ventricular hypertrophy detected by echocardiogram. After a wash-out period, all patients were given placebo followed by the active drug benazepril at a dose of 10 mg once a day. For those patients who did not achieve a satisfactory control of the blood pressure (BP) 25 mg of chlorthalidone was added. All patients underwent 180 days of benazepril treatment. RESULTS--The ABP was gradually controlled as follow at seated position the systolic BP changed from 156.05 +/- 5.07 mmHg to 129 +/- 3.74 mmHg (p < 0.001) and the diastolic BP from 99.74 +/- 1.59 mmHg to 81.8 +/- 2.27 mmHg (p < 0.001). At orthostatic position the systolic BP changed from 156.9 +/- 5.35 mmHg to 124.28 +/- 5.33 mmHg (p < 0.001) and the diastolic BP from 101.7 +/- 1.34 to 81.36 +/- 2.81 (p < 0.001). The heart rate did not change significantly during the study. The LVMI decreased significantly from 182.4 +/- 9.2g/m2 to 122.6 +/- 4.2g/m2 (p < 0.001). CONCLUSION--Our data revealed that 100 per cent of the patients achieved satisfactory degrees of LVMI regression and in 34 per cent there was a normalization of it
Key words
Full text:
1
Index:
LILACS
Main subject:
Benzazepines
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Hypertrophy, Left Ventricular
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Hypertension
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Antihypertensive Agents
Type of study:
Clinical_trials
Limits:
Female
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Humans
/
Male
Language:
Pt
Journal:
Arq. bras. cardiol
Journal subject:
CARDIOLOGIA
Year:
1994
Type:
Article