Let there be light: signal transduction in a mammalian circadian system
Braz. j. med. biol. res
;
29(1): 131-40, Jan. 1996. tab, ilus
Article
in English
| LILACS
| ID: lil-161664
RESUMO
Mammalian circadian rhythms are controlled by a biological clock located in the hypothalamic suprachiasmatic nuclei (SCN). This clock is entrained by light through a retinohypothalamic pathway that interacts with the SCN through glutamate neurotransmission. Light pulses during the subjective night induce phase shifts of behavioral rhythms, and also trigger intracellular changes such as the expression of immediate-early genes and activation of transcription factors. In this review, we present a model of the signal transduction pathway leading to photic synchronization of the circadian clock, including the activity of specific second messenger systems, gene expression, and interaction between potential agents capable of producing phase shifts.
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Index:
LILACS (Americas)
Main subject:
Suprachiasmatic Nucleus
/
Biological Clocks
/
Signal Transduction
/
Circadian Rhythm
/
Light
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1996
Type:
Article
/
Congress and conference
/
Project document
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