Facilitatory role of serotonin (5-HT) in the control of thyrotropin releasing hormone/thyrotropin (TRH/TSH) secretion in rats
Braz. j. med. biol. res
;
29(5): 677-83, May 1996. tab, graf
Article
in English
| LILACS
| ID: lil-182555
ABSTRACT
In order to investigate the role of serotonin in the regulation of thyrotropin (TSH) secretion, control and propylthiouracil (PTU)treated male Wistar rats weighing approximately 250 g were subjected to ip injections of methysergide (MET, 10 mug/l00 g body weight), a serotonergic receptor blocker, and killed 60 min later by decapitation. Serum and pituitary concentrations of TSH were measured by radioimmunoassay. In addition, the pituitary release of TSH was estimated in an in vitro system in which pituitary glands were incubated with hypothalamic extracts. MET treatment led to a decrease in pituitary (94.12 ñ 18.55 vs 199.30 ñ 31.47 mug/mg, N = 20), and serum (l.95 ñ 0.92 vs 4.26 ñ 1.40 ng/ml, N = 20) TSH concentration (P
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Index:
LILACS (Americas)
Main subject:
Propylthiouracil
/
Thyrotropin
/
Serotonin
/
Thyrotropin-Releasing Hormone
/
Methysergide
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1996
Type:
Article
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MEDLINE
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LILACS
LIS
Search on Google
Index:
LILACS (Americas)
Main subject:
Propylthiouracil
/
Thyrotropin
/
Serotonin
/
Thyrotropin-Releasing Hormone
/
Methysergide
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1996
Type:
Article