Factores histológicos como elemento de valor pronóstico en atresia de vias biliares / Histologic factors as an element of prognosis value in biliary atresia
Acta gastroenterol. latinoam
; 26(3): 177-81, 1996. tab, graf
Article
in Es
| LILACS
| ID: lil-186208
Responsible library:
BR1.1
RESUMO
Biliary atresia (BA) is one of the biliary tree anomaly more frecuent. Occurs in about 0,8 to 1/10.000 live births. BA is defined as a progressive biliary tree. The prognosis depends ond the age of the diagnosis and precocity surgery. We present the resuls of a retrospective analysis of 71 RA carried out at the Garrahan Hospital from 1987 to 1993. 47 were female and 24 were male. Age ranged from 45 to 120 days of life. This study involved a consecutive series of 58 patients with histopathologic study of Porta-hepatis (PH) and liver biopsy obteined during the Kasai. The purpose of this study was to determine the value of histological factors as type of PH and hepatocitic giant cell transformation (GCT). 82.8 per cent had favorable type of PH and the CCT was mild in 84,5 per cent. 72,4 per cent had bad outcome and was independent of the type of PH. Neither of them were statiscaly significant with survive and evolution. In our serice neither PH non CGT were predicators of a bad outcome. There were good outcome in 27.5 per cent, died 37,9 per cent and 10.3 per cent undergo liver transplantation. The precocity in a diagnosis and surgical procedure before two months of age are the most important factors in correlation with survival. Others immunomorphologic factors must be estudied in BA that explained the ethiopatogenic process. Orthotopic liver transplantation is the succesful therapy in childrens with BA.
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Index:
LILACS
Main subject:
Biliary Atresia
/
Liver
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Female
/
Humans
/
Infant
Language:
Es
Journal:
Acta gastroenterol. latinoam
Journal subject:
GASTROENTEROLOGIA
Year:
1996
Type:
Article