Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat
Acta physiol. pharmacol. ther. latinoam
; 46(3): 149-58, 1996. tab, graf
Article
in En
| LILACS
| ID: lil-187279
Responsible library:
BR1.1
RESUMO
Urinary parameters related to acid base homeostasis were studied in adrenalectomized rats (ADX) as well as in ADX treated with physiological doses of corticosterone (B), aldosterone (aldo) or 18-Hydroxycorticosterone (l8HOB) during 1,3 or 5 days, under basal conditions and after gravage with 200 mM HCI. The results showed a) a persistent effect of B and l8HOB increasing titratable acidity principally in response to acidosis; b) an increased phosphate elimination in acidotic B treated ADX on the first day, and in 18 HOB treated ADX on days 3 and 5; c) pronounced increases in blood pH and blood bicarbonate levels provoked by the three steroids on day 1; d) increments of ammonium elimination in response to acidosis by aldo treatmets on the first day, while B and l8HOB increase ammonium elimination under almost all conditions during the whole experiment; e) the effects of B and 18 HOB would be independent of an increase in sodium retention as well as glomerular filtration rate.
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Index:
LILACS
Main subject:
Corticosterone
/
Aldosterone
/
Homeostasis
/
Kidney
Limits:
Animals
Language:
En
Journal:
Acta physiol. pharmacol. ther. latinoam
Journal subject:
FARMACOLOGIA
/
FISIOLOGIA
/
TERAPEUTICA
Year:
1996
Type:
Article