Involvement of hippocampal AMPA glutamate receptor changes and the cAMP/protein kinase A/CREB-P signaling pathway in memory consolidation of an avoidance task in rats
Braz. j. med. biol. res
; 30(8): 961-5, Aug. 1997. graf
Article
in En
| LILACS
| ID: lil-197252
Responsible library:
BR1.1
ABSTRACT
Training in step-down inhibitory avoidance (0.3-mA footshock) is followed by biochemical changes in rat hippocampus that strongly suggest an involvement of quantitative changes in glutamate AMPA receptors, followed by changes in the dopamine D1 receptor/cAMP/protein kinase A (PKA)/CREB-P signalling pathway in memory consolidation. AMPA binding to its receptor and levels of the AMPA receptor-specific subunit GluR1 increase in the hippocampus within the first 3 h after training (20-70 per cent). Binding of the specific D1 receptor ligand, SCH23390, and cAMP levels increase within 3 or 6 h after training (30-100 per cent). PKA activity and CREB-P levels show two peaks a 35-40 per cent increase 0 h after training, and a second increase 3-6 h later (35-60 per cent). The results correlate with pharmacological findings showing an early post-training involvement of AMPA receptors, and a late involvement of the D1/cAMP/PKA/CREB-P pathway in memory consolidation of this task.
Full text:
1
Index:
LILACS
Main subject:
Avoidance Learning
/
Signal Transduction
/
Cyclic AMP Response Element-Binding Protein
/
Receptors, AMPA
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Cyclic AMP-Dependent Protein Kinases
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Hippocampus
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Memory
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1997
Type:
Article
/
Congress and conference