Asociación entre heterocigocidad materna para cinco grupos sanguíneos y éxito reproductivo / Association between maternal heterozygosity for five blood groups and reproductive success
Rev. méd. Chile
; 126(1): 27-31, ene. 1998. ilus
Article
in Es
| LILACS
| ID: lil-210406
Responsible library:
CL1.1
RESUMO
Background:
In man, blood groups are polymorphic genetic systems. Maternal fetal incompatibility phenomena should lead to an elimination rather than a maintenance of these polymorphisms. Apossible mechanism that could explain the persistence of these polymosphisms in natural populations is a selective reproductive advantage of heterozygous individuals.Aim:
To explore the relationship between maternal heterozygosity for five blood grups and some obstetrical variables related to gestational success. Material andmethods:
Using a case control design, to every mother giving birth to a malformed child a consecutive mother, whose offspring was normal, was assigned as control. All women were typified for ABO, Rh, kidd, MNSs and Duffy blood groups.Results:
Two hundred two women were studiend. There was only one stillbirth, born from a heterozygous mother for all analyzed loci. Mothers that were heterozygous or homozygous for all loci had a higher frequency of malformed children. Women homozygous for all loci had a higher frequency of living offspring than the rest of the sample.Conclusions:
Heterozygous mothers for these genetic systems have a reproductive disadvantage
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Index:
LILACS
Main subject:
Reproduction
/
Blood Group Antigens
/
Genetic Carrier Screening
Type of study:
Risk_factors_studies
Limits:
Female
/
Humans
/
Newborn
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
1998
Type:
Article