Effect of metoclopramide on blood pressure during handgrip test in hypertensive patients / Efecto de la metaclopramida sobre la presión sanguinea durante la prueba handgrip en pacientes hypertensivos
Arch. venez. farmacol. ter
; 15(2): 64-7, 1996. tab
Article
in Es
| LILACS
| ID: lil-218730
Responsible library:
VE1.1
ABSTRACT
Twenty two (22) hypertensive patients were studied during handgrip test before and during metoclopramide treatment. Metoclopamide was intravenously administered at the rate of 7,5 µg/kg/min during a period of 30 min. Two placebo periods before and after metoclopramide infusion were employed. There was an increase of blood pressure and heart rate during handrgrid test; however, metaclopramide decreased blood pressure prior to handgrip test. In labetalol pretreated hypertensive patients (600-800 mg/daily po, during 7 days period), metoclopramide decreased greater blood pressure before and after handgrip test. Postmenopausal women reacted greater that premenopausal women. It appers that premenopausal women exhibit a vasculoprotecting effect during handgrip which should be attributed to estrogen secretion
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Index:
LILACS
Main subject:
Patients
/
Blood Pressure
/
Hypertension
/
Metoclopramide
Type of study:
Clinical_trials
Limits:
Female
/
Humans
Language:
Es
Journal:
Arch. venez. farmacol. ter
Journal subject:
FARMACOLOGIA
/
TERAPEUTICA
Year:
1996
Type:
Article