Adult gerbil epidermal cells resistant to terminal differentiation associated with initiation of carcinogenesis
Acta cient. venez
;
48(3): 134-8, 1997. ilus
Article
in English
| LILACS
| ID: lil-228495
ABSTRACT
In order to identify the cellular basis of the gerbil skin unresponsiveness to two-stage carcinogenesis, it was studied the effect of an initiating dose of carcinogen on the biological behaviour of gerbil skin. Treatment of adult gerbil epidermal cells either in vivo or in vitro with 3-methylcholanthrene yielded cells which were resistant to terminal differentiation induced by calcium. These results support the concept derived from the mouse model system of skin carcinogenesis in which initiation is associated with an altered program of epidermal differentiation. The results also suggest that relative resistance of gerbil skin to two-stage carcinogenesis is related to promotion stage
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Index:
LILACS (Americas)
Main subject:
Carcinogens
/
Epidermis
Type of study:
Risk factors
Limits:
Animals
Language:
English
Journal:
Acta cient. venez
Journal subject:
Science
Year:
1997
Type:
Article
Affiliation country:
Brazil
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