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Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study
Sales, Magaly M.; Lucca, Edmundo J. de; Yamashita, Seizo; Saad, Luis Henrique Cury.
Affiliation
  • Sales, Magaly M.; Universidade Estadual Paulista. Instituto de Biociências. Departamento de Genética.
  • Lucca, Edmundo J. de; Universidade Estadual Paulista. Instituto de Biociências. Departamento de Genética.
  • Yamashita, Seizo; Universidade Estadual Paulista. Faculdade de Medicina. Departamento de Doenças Tropicais e Diagnóstico por Imagem.
  • Saad, Luis Henrique Cury; Universidade Estadual Paulista. Faculdade de Medicina. Departamento de Cirurgia e Ortopedia.
Genet. mol. biol ; 22(1): 17-20, Mar. 1999. tab, ilus
Article in En | LILACS | ID: lil-243512
Responsible library: BR1.1
RESUMO
Human peripheral blood lymphocytes from 10 patients with familial adenomatous polyposis (FAP) showed a significantly higher incidence of chromatid breaks when compared to cells from 10 normal individuals, after exposure to bleomycin (BLM) during the G2 phase. However, no significant increase in bleomycin sensitivity was observed in lymphocytes from 10 patients with sporadic adenomatous polyps (AP) vs. 10 normal individuals (P = 0.67). Individuals that exhibited an average number of chromatid breaks per cell higher than 0.80 were considered sensitive to the drug. No control showed susceptibility to BLM, as compared to 3 out of 20 patients.
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Full text: 1 Index: LILACS Main subject: Bleomycin / Chromatids / Adenomatous Polyposis Coli / Antibiotics, Antineoplastic Type of study: Diagnostic_studies Limits: Adult / Aged80 / Female / Humans / Male Language: En Journal: Genet. mol. biol Journal subject: GENETICA Year: 1999 Type: Article
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Full text: 1 Index: LILACS Main subject: Bleomycin / Chromatids / Adenomatous Polyposis Coli / Antibiotics, Antineoplastic Type of study: Diagnostic_studies Limits: Adult / Aged80 / Female / Humans / Male Language: En Journal: Genet. mol. biol Journal subject: GENETICA Year: 1999 Type: Article