Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum
Braz. j. med. biol. res
; 33(2): 237-40, Feb. 2000. tab
Article
in En
| LILACS
| ID: lil-252301
Responsible library:
BR1.1
RESUMO
Dopamine nigrostriatal neurons are important for motor control and may contain a particularly dense population of ryanodine receptors involved in the control of dopamine release. To test this hypothesis, we used a classical model of unilateral selective lesion of these neurons in rats based on 6-hydroxydopamine (6-OHDA) injection into the substantia nigra. Binding of [3H]-GBR 12935, used as a presynaptic marker since it labels specifically the dopamine uptake complex, was dramatically decreased by 83-100 percent in striatum homogenates after 6-OHDA lesion. On the contrary, no reduction of [3H]-ryanodine binding was observed. The present data indicate that [3H]-ryanodine binding sites present in rat striatum are not preferentially localized in dopaminergic terminals
Full text:
1
Index:
LILACS
Main subject:
Dopamine
/
Oxidopamine
/
Adrenergic Agents
/
Ryanodine Receptor Calcium Release Channel
/
Corpus Striatum
/
Neuroleptic Malignant Syndrome
/
Neurons
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
2000
Type:
Article