Estudio abierto no comparativo con mupirocina en el tratamiento de pacientes pediátricos con infecciones de la piel y tejidos blandos / Open study of Mupirocin in the treatment of skin and soft tissue infections in pediatric patients
Acta pediátr. costarric
; 11(1): 20-6, 1997.
Article
in Es
| LILACS
| ID: lil-278759
Responsible library:
CR1.1
ABSTRACT
ObjetiveTo analyze the clínical and bacteriologicalefficacy of mupirocina in the treatment of pediatric patients with skin and solf tissue infectons. Design:
Prospective, open, non-comparative clinical trial. Materials andmethods:
Patiens between 6 months and 12 years old with the clinical and bacteriological diagnosis of a skin of soft tissue infection were included in this trial. Material from the affected site was obtained for culture and susceptibility testing using the kirby - Bauer techique. All the patients were treated with topical mupirocin for 7 days. Follow up visits for clinical evaluations and adverse events were perform during (day 3) and at the end of therapy (day 7-8).Results:
From 32 patients enrolled, 23 were considered evaluable. The initial diagnosis were impetigo (29 cases) and pyodermitis (3 cases). The ethiologic agents obtained from the 23 evaluable patients were S. aureus (14), S pyogenes (2), S. aureus and S. Pyogenes (1), Candida albicans (1) and Klebsiella (2). 87.7 porcent (13/5), Of the S. aureus strains and 100 porcent (2/2) of the S. pyoenes strains were mupirocin susceptible. The 2 klepsiella sp. strains were mupirocin resistant. Twenty of the 23 evaluable patients (87 porcent) were considered cured or improved at the end of therapy.Conclusion:
The results of this clinical trial, together with other larger trials, suggest that topical mupirocin is a valid and safe alternative for this treatment of pediatric patients with skin and soft tissue infectious
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Index:
LILACS
Main subject:
Skin
/
Skin Diseases, Infectious
/
Mupirocin
/
Soft Tissue Infections
Limits:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
Country/Region as subject:
America central
/
Costa rica
Language:
Es
Journal:
Acta pediátr. costarric
Journal subject:
PEDIATRIA
Year:
1997
Type:
Article