Expression of c-erbB-2, p53 and c-myc proteins in male breast carcinoma: Comparison with traditional prognostic factors and survival
Braz. j. med. biol. res
;
34(7): 887-894, July 2001. ilus, tab
Article
in English
| LILACS
| ID: lil-298672
ABSTRACT
There are few data evaluating biological markers for men with breast cancer. The purpose of the present study was to analyze the expression of the oncogenes c-erbB-2 and c-myc and of the suppressor gene p53 by immunohistochemical techniques in archival paraffin-embedded tissue blocks of 48 male breast cancer patients, treated at the A.C. Camargo Cancer Hospital, Säo Paulo, SP, Brazil. The results were compared with clinicopathological prognostic features. Immunopositivity of c-erbB-2, p53 and c-myc was detected in 62.5, 16.7 and 20.8 percent of the cases analyzed, respectively. Estrogen and progesterone receptors were positive in 75 and 69 percent of the cases, respectively. Increasing staging was statistically associated with c-erbB-2 (P = 0.04) and weakly related to p53 positivity (P = 0.06). No significant correlation between specific survival rate (determined by the log rank test) and the molecular markers analyzed was found, whereas the number of compromised lymph nodes and advanced TNM (tumor, node, metastasis) staging were associated with diminished survival
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Biomarkers, Tumor
/
Genes, p53
/
Tumor Suppressor Protein p53
/
Proto-Oncogene Proteins c-myc
/
Receptor, ErbB-2
/
Breast Neoplasms, Male
Type of study:
Prognostic study
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital do Câncer A.C. Camargo/BR
/
Instituto Adolpho Lutz/BR
/
Instituto Ludwig de Pesquisa sobre o Câncer/BR
/
Universidade de Säo Paulo/BR
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