Comparison of positivity frequency of bcl-2 expression in prostate adenocarcinoma with low and high Gleason score
São Paulo med. j
;
119(4): 138-141, July 2001. ilus, tab
Article
in English
| LILACS
| ID: lil-302319
RESUMO
CONTEXT Multiple genetic and epigenetic factors have been implicated in the oncogenesis and progression of prostate cancer. The major difficulty is in that the clinical management stems from the reality that reliable and accurate prognostic biomarkers are not available and that effective treatment regimens forming hormone-resistant prostate cancers are yet to be developed. Among the most important regulators of apoptosis and programmed cell death is the bcl-2 gene and its related proteins. Elevated levels of bcl-2 protein may contribute to the progression of prostate cancers to a metastatic and hormone-insensitive state characterized by poor responses to chemotherapy. OBJECTIVE:
To characterize the expression of bcl-2 proteins as a prognostic factor in humans.DESIGN:
A retrospective approach.SETTING:
Urology section, Federal University of Säo Paulo. DIAGNOSTIC TEST USED Immunohistochemical analysis using bcl-2 protein antibody and normal staining by hematoxylin-eosin. MAIN MEASUREMENTS Prognostic relations and protein expression were evaluated considering the total sample (28) divided into two groups, high (8 to 10) and low (2 to 4), separated according to the histological differentiation grade (Gleason score) with 10 and 18 samples, respectively.RESULTS:
The differentiation of grade into two groups separated according to the Gleason score in low and high types presented different bcl-2 expression (P < 0.001).CONCLUSION:
The higher frequency of bcl-2 immunostaining in tumor samples was observed in association with more advanced Gleason scores and suggests that an increase in the ratio of this anti-apoptotic protein often occurs during progression of prostate cancers
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Prostatic Neoplasms
/
Adenocarcinoma
/
Proto-Oncogene Proteins c-bcl-2
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Säo Paulo/BR
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