New enamine derivatives of lapachol and biological activity
An. acad. bras. ciênc
; 74(2): 211-221, June 2002. ilus, tab
Article
in En
| LILACS
| ID: lil-314019
Responsible library:
BR1.1
ABSTRACT
A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells
Full text:
1
Index:
LILACS
Main subject:
Naphthoquinones
/
Amines
/
Antineoplastic Agents, Phytogenic
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
An. acad. bras. ciênc
Journal subject:
CIENCIA
Year:
2002
Type:
Article