Serum factors inhibitory for in vitro development of Plasmodium falciparum blood-stage parasites
Mem. Inst. Oswaldo Cruz
; 89(Suppl.2): 17-21, 1994.
Article
in En
| LILACS
| ID: lil-319959
Responsible library:
BR1.1
ABSTRACT
Sera from 29 individuals residing in a malaria-endemic region of Colombia were evaluated by an inhibition assay for their capacity to retard the growth of Plasmodium falciparum in vitro. The inhibitory activity was found to be independent of antibody activity. Furthermore, the degree of inhibition of parasite development was variable, depending on the parasite isolate used for the assay and the season of malaria transmission. We selected sera with high inhibitory activity and carried out partial analytical characterization by anion exchange fast protein liquid chromatography (FPLC) to identify the chemical nature of the inhibitory factor(s). The results suggested that the in vitro inhibitory activity might result from the additive effect of different molecules. It appears that these molecules could be non-specifically induced by stimulation of the immune system, they seem to play a role in the immunity to malaria.
Full text:
1
Index:
LILACS
Main subject:
Plasmodium falciparum
/
Immune Sera
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
1994
Type:
Article