Perfil lipídico, microalbuminúria e pressão arterial sistêmica em pacientes com diabetes insulino-dependente / Lipids, Microalbuminuria and Systemic Blood Pressure in Patients with InsulinDependent Diabetes Mellitus
Arq. bras. cardiol
;
68(2): 85-89, Fev. 1997. tab
Article
in Portuguese
| LILACS
| ID: lil-320360
RESUMO
PURPOSE: To determine the association between lipids, microalbuminuria and systemic blood pressure. Urinary albumin excretion rate (AER) was determined in timed overnight urine samples by radioimmunoassay. Microalbuminuria was defined when two out of three urine samples had AER ranging 20-200 micrograms/min. Lipids were determined by colorimetric methods (total cholesterol, HDL cholesterol and triglycerides). METHODS: Fifty patients with insulin dependent diabetes mellitus (28 females, 22 males) aged 21.9 +/- 7 years and with diabetes duration of 6.8 +/- 5.8 years attending the outpatients diabetes clinic were studied cross-sectionally. RESULTS: Microalbuminuria was present in 12of our patients. A high systolic blood pressure (SBP) was found in microalbuminuric patients (p = 0.003). No difference concerning serum lipids were found in comparison between normo and microalbuminuric patients, although 20of all patients had increased cholesterol and LDL cholesterol and 4had high HDL cholesterol and triglycerides levels. Stepwise multiple regression analysis showed that SBP was the only significant independent variable to influence AER (r = 0.42 r2 = 0.18 p = 0.002). CONCLUSION: Although in our study, microalbuminuria was associated only with SBP, the independent alteration of lipids in young IDDM patients must be considered as a possible additional risk factor for cardiovascular disease.
Full text:
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Index:
LILACS (Americas)
Main subject:
Diabetes Mellitus, Type 1
/
Albuminuria
/
Arterial Pressure
/
Lipids
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
Portuguese
Journal:
Arq. bras. cardiol
Journal subject:
Cardiology
Year:
1997
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade do Estado do Rio de Janeiro (UERJ)/BR
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