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Genetic diversity and differentiation in natural Plasmodium falciparum populations inferred by molecular typing of the merozoite surface proteins 1 and 2
Pereira, Fabrício J. T; Cordeiro, José A; Hoffmann, Erika H. E; Ferreira, Marcelo U.
Affiliation
  • Pereira, Fabrício J. T; Laboratório de Parasitologia Molecular. BR
  • Cordeiro, José A; Faculdade de Medicina de Säo José do Rio Preto. Departamento de Epidemiologia e Saúde Coletiva. Säo José do Rio Preto. BR
  • Hoffmann, Erika H. E; Universidade de Säo Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Säo Paulo. BR
  • Ferreira, Marcelo U; Laboratório de Parasitologia Molecular. BR
Rev. Soc. Bras. Med. Trop ; 35(5): 527-530, Sept.-Oct. 2002. tab, graf
Article in En | LILACS | ID: lil-328007
Responsible library: BR1.1
ABSTRACT
Genetic diversity and differentiation, inferred by typing the polymorphic genes coding for the merozoite surface proteins 1 (Msp-1) and 2 (Msp-2), were compared for 345 isolates belonging to seven Plasmodium falciparum populations from three continents. Both loci yielded similar estimates of genetic diversity for each population, but rather different patterns of between-population differentiation, suggesting that natural selection on these loci, rather than the transmission dynamics of P. falciparum, determines the variation in allele frequencies among populations
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Full text: 1 Index: LILACS Main subject: Plasmodium falciparum / Genetic Variation / Protozoan Proteins / Merozoite Surface Protein 1 / Antigens, Protozoan Limits: Animals / Humans Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2002 Type: Article
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Full text: 1 Index: LILACS Main subject: Plasmodium falciparum / Genetic Variation / Protozoan Proteins / Merozoite Surface Protein 1 / Antigens, Protozoan Limits: Animals / Humans Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2002 Type: Article