Autoantibodies, human T lymphotropic virus type 1 and type 1 diabetes mellitus in Jamaicans
West Indian med. j
; West Indian med. j;51(3): 153-156, Sept. 2002.
Article
in En
| LILACS
| ID: lil-333262
Responsible library:
BR1.1
RESUMO
The clinical characteristics, autoantibody profiles and seroprevalence of human T lymphotropic virus Type 1 (HTLV-1) were assessed in 30 Jamaican patients with Type 1 diabetes mellitus. Two hundred and fifty-two blood donors and 108 patients with Graves' disease were included as controls for the HTLV-1 component of the study. The mean age of onset of diabetes mellitus was 20.5 +/- 9.2 years and the mean duration of diabetes mellitus was 10.5 +/- 6.1 years. The remarkable clinical data included an absence of other associated organ-specific autoimmune diseases, and clinical evidence and history of congenital rubella in one patient. Islet cell cytoplasmic antibodies (ICA) were absent but 17 (5/30) of the diabetic patients tested positive for glutamic acid decarboxylase (GAD) antibodies. No other organ-specific autoantibodies were detected but non-organ-specific autoantibodies were present in 9 (30) of the sera of diabetic patients. The seroprevalence of HTLV-1 in the patients with diabetes mellitus was significantly higher than that in the healthy controls (17 (5/30) versus 4 (11/252), p = 0.05). Autoantibodies were found in the sera of 4/5 (80) of the diabetic patients who were positive for HTLV-1. None of the patients with onset of diabetes mellitus below age 15 years was HTLV-1 positive. The likely polyaetiological nature of Type 1 diabetes mellitus in Jamaicans is being further investigated at the molecular level.
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Index:
LILACS
Main subject:
Autoantibodies
/
HTLV-I Antibodies
/
Diabetes Mellitus, Type 1
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Caribe ingles
/
Jamaica
Language:
En
Journal:
West Indian med. j
Journal subject:
MEDICINA
Year:
2002
Type:
Article