Plasmaféresis en el síndrome de Guillain-Barré / Plasmapheresis in Guillain-Barre syndrome
Gac. méd. Méx
; 138(6): 527-531, Nov.-Dec. 2002.
Article
in Es
| LILACS
| ID: lil-334529
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of early therapeutic plasmapheresis in severely affected patients with Guillain-BarrÚ syndrome (GBS). PATIENTS ANDMETHOD:
Patients between 16 to 70 years of age, with GBS according to NINCDS criteria, in stage > or = 3 of Huges severity score and with less than 7 days of onset of symptoms were admitted for therapeutic plasmapheresis. All patients completed a total of five sessions of plasma exchange every other day using 25 albumin and saline in a 11 proportion. Follow-up was performed for 6 months. Friedman and Wilcoxon tests were done to establish differences within groups.RESULTS:
A total of 34 patients were admitted to the study. The time span between onset of symptoms and admission to the study was 4 days (median). Fourteen (41) required mechanical ventilation. Clinical progression of the syndrome was observed during the first two sessions of plasma-pheresis. Improvement in motor function by Huges score was observed only after fourth session of plasma exchange (p < 0.05). Two patients did not improve, and one died.CONCLUSIONS:
Clinical improvement in GBS during early therapeutic plasmapheresis occurs only after the fourth session of plasma exchange.
Full text:
1
Index:
LILACS
Main subject:
Plasmapheresis
/
Guillain-Barre Syndrome
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Es
Journal:
Gac. méd. Méx
Journal subject:
MEDICINA
Year:
2002
Type:
Article