Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest
Braz. j. med. biol. res
; 37(3): 379-384, Mar. 2004. tab
Article
in En
| LILACS
| ID: lil-356608
Responsible library:
BR1.1
ABSTRACT
More than 20 percent of the world's biodiversity is located in Brazilian forests and only a few plant extracts have been evaluated for potential antibacterial activity. In the present study, 705 organic and aqueous extracts of plants obtained from different Amazon Rain Forest and Atlantic Forest plants were screened for antibacterial activity at 100 µg/ml, using a microdilution broth assay against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli. One extract, VO581, was active against S. aureus (minimum inhibitory concentration (MIC) = 140 µg/ml and minimal bactericidal concentration (MBC) = 160 µg/ml, organic extract obtained from stems) and two extracts were active against E. faecalis, SM053 (MIC = 80 µg/ml and MBC = 90 µg/ml, organic extract obtained from aerial parts), and MY841 (MIC = 30 µg/ml and MBC = 50 µg/ml, organic extract obtained from stems). The most active fractions are being fractionated to identify their active substances. Higher concentrations of other extracts are currently being evaluated against the same microorganisms.
Full text:
1
Index:
LILACS
Main subject:
Plants, Medicinal
/
Gram-Negative Bacteria
/
Gram-Positive Bacteria
/
Anti-Bacterial Agents
Type of study:
Diagnostic_studies
/
Screening_studies
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
2004
Type:
Article
/
Congress and conference
/
Project document