Naturally acquired immunity to Haemophilus influenzae type B in healthy Cuban children
Mem. Inst. Oswaldo Cruz
; 99(7): 687-689, Nov. 2004. tab
Article
in En
| LILACS
| ID: lil-391595
Responsible library:
BR1.1
RESUMO
We have evaluated the prevalence of antibody to immunogenicity of Haemophilus influenzae type b (Hib) in a group of 4 to 5 years old healthy children, who were too old to be included in the first vaccinated cohort when Hib vaccination begun in Cuba in 1999. Serum capsular polysaccharide specific IgG antibody concentrations were measured in 974 healthy children, between February and May 2002. The prevalence of Hib nasopharyngeal carriage was also estimated. The majority of children (99.7 percent) had more than 1 µg/ml of antibody. The preliminary report of the nasopharyngeal cultures was positive for H. influenzae in 16 children, but in only one was confirmed as Hib after serotyping (0.1 percent Hib nasopharyngeal carrier). These results provide evidence that in Cuba the natural active immunity to Hib can be acquired at an early age.
Full text:
1
Index:
LILACS
Main subject:
Polysaccharides, Bacterial
/
Immunoglobulin G
/
Haemophilus influenzae type b
/
Immunity, Innate
/
Antibodies, Bacterial
Type of study:
Prevalence_studies
/
Risk_factors_studies
Limits:
Child, preschool
/
Humans
Country/Region as subject:
Caribe
/
Cuba
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2004
Type:
Article