Efeitos hemodinâmicos sistêmicos e regionais da cocaína em cães anestesiados com halotano e sevoflurano / Systemic and regional hemodynamic effects of cocaine in dogs anesthetized with halothane and sevoflurane

RESUMO

O abuso da cocaína é frequente, podendo levar a óbito por arritmias cardíacas (fibrilação ventricular) infarto agudo do miocárdio (espasmos nas coronárias). Entretanto, é pouco conhecido o efeito da cocaína na perfusão do território esplâncnico e na mucosa gastrointestinal tem sido implicada na gênese da sepse e disfunção de múltiplos órgãos e sistemas. Fato este, atualmente bem explorado através da tonomeria gástrica, podendo assim melhorar o prognóstico na terapêutica em pacientes graves. /We made a transversal study in a homogeneous group of rheumatic patients with chronic severe aortic regurgitation. We determined plasma levels of the following proinflamatory cytokines Tumor necrosis factor-alpha ( TNF ) and its soluble receptors type I and II ( sTNFR I and sTNFR II ), Interleukin-6 ( IL-6 ) and its soluble receptor ( IL-6R ), interleukin-1 beta ( IL-1 beta ), antagonist of the IL-1 receptor ( IL1-RA ) and endothelin-1. The -308 genetic polimorphism os the TNF gene was made. Plasma levels of TNF, IL-6 and sTNFRI were increased in asymptomatic and symptomatic in relation to controls. There were similar levels of cytokines in asymptromatic and symptomatic patients. The polimorphism TNF 1/2 was more frequent in asymptomatic patients. Increase of ventricular diameters was correlated to decrease...