Comparative in vitro activities of seven new beta-lactams, alone and in combination with beta-lactamase inhibitors, against clinical isolates resistant to third generation cephalosporins
Braz. j. infect. dis
; 10(1): 22-25, Feb. 2006. tab
Article
in En
| LILACS
| ID: lil-428711
Responsible library:
BR1.1
ABSTRACT
We examined the drug susceptibility pattern of Gram-negative bacilli to seven new beta-lactams. A total of 277 non-duplicate gramnegative bacilli strains belonging to the Enterobacteriaceae family, Pseudomonas and Acinetobacter species, isolated from various clinical samples were tested for susceptibility to imipenem, piperacillin/tazobactam, cefoperazone/sulbactam, ticarcillin/clavulanate, cefdinir, cefepime and cefpirome with the disk diffusion technique. The percentage resistance was low for imipenem (7.2 percent), piperacillin/tazobactam (2.8 percent), cefoperazone/sulbactam (5.4 percent). However, a high frequency of resistance was observed to ticarcillin/clavulanate (83.9 percent), cefdinir (70.6 percent), cefepime (45.5 percent) and cefpirome (84.4 percent). We conclude that imipenem, piperacillin/tazobactam and cefoperazone/sulbactam are effective antibiotics in our environment, whereas ticarcillin/clavulanate, cefdinir, cefepime and cefpirome are relatively uneffective.
Full text:
1
Index:
LILACS
Main subject:
Beta-Lactamases
/
Beta-Lactams
/
Enzyme Inhibitors
/
Gram-Negative Bacteria
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Braz. j. infect. dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2006
Type:
Article