Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínico / Osteonecrosis associated with the use of biphosphonates: Case report
Rev. méd. Chile
;
134(9): 1161-1165, sept. 2006. ilus
Article
in Spanish, English
| LILACS
| ID: lil-438419
ABSTRACT
Biphosphonates reduce the risk of skeletal events and are currently part of standards of therapy in myeloma. Recently, zoledronate and pamidronate have been linked to osteonecrosis of the jaw, specially after surgical dental procedures. We report a 84 year-old man with multiple myeloma who developed spontaneous osteonecrosis of both jaws, after 36 months of therapy with zoledronate with a cumulative dose of 136 mg. We discuss the pathogenic mechanisms, and review the recommendations on prevention and management of this new complication for neoplastic patients under prolonged therapy with biphosphonates.
Full text:
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Index:
LILACS (Americas)
Main subject:
Osteonecrosis
/
Jaw Diseases
/
Diphosphonates
/
Bone Density Conservation Agents
/
Imidazoles
/
Multiple Myeloma
Type of study:
Practice guideline
/
Risk factors
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
English
/
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2006
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Clínica Alemana de Santiago/CL
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