Efeito aterogênico da poluição atmosférica: associação aos anticorpos anti LDLox e anti peptídeo D da apoB e aos aspectos morfométricos e inflamatórios / Aterogenic effect of air pollution: association to anti-oxLDL and anti peptide D-ApoB and in aspects morphometric and inflamatory
São Paulo; s.n; 2006. [131] p. ilus, tab, graf.
Thesis
in Pt
| LILACS
| ID: lil-443937
Responsible library:
BR66.1
Localization: BR66.1; W4.DB8, S656ea, FM-2
RESUMO
O objetivo deste estudo foi identificar genes diferencialmente expressos entre adenocarcinoma de pâncreas de pacientes com e sem diabetes melito, utilizando microarranjos de oligonucleotídeos hibridizados com cRNA de tumores advindos de pacientes nessas duas condições. Observou-se nos microarranjos que 293 genes estavam pelo menos duas vezes mais expressos nos tumores dos pacientes com diabetes melito. Outros 297 genes estavam mais expressos nos tumores dos não-diabéticos...
ABSTRACT
The objective of the present study was to identify differentially expressed genes between pancreatic adenocarcinoma from patients who had and who did not have diabetes mellitus. Oligonucleotides bioarrays were hybridized with complementary RNA from tumors of two diabetic and two normotolerant patients. It was observed that 293 genes were at least twice more expressed in tumors from diabetic patients. Other 297 genes were more expressed in tumors from normotolerant patients. In quantitative RT-PCR performed in 12 tumors samples, FAM3D mRNA was more expressed in tumors from diabetic than in tumors from non-diabetic patients...
Full text:
1
Index:
LILACS
Main subject:
Arteriosclerosis
/
Autoantibodies
/
Air Pollution
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
Pt
Year:
2006
Type:
Thesis